Ludogorets only managed to score one goal and suffered a 4-1 loss in the first leg. They face a tough visit and all they can hope for is to exit with dignity. However, their performances as a guest team haven't been impressive. They lost five of their six away games in all competitions this season.
Ajax seems likely to progress to the next round. They were leading 3-0 by halftime in Razgrad and have a comfortable lead before the second leg. It's a big challenge for Ludogorets, and even if they relax for the second match, it's unlikely they will let anything shocking happen.
Even if Ajax doesn't put much effort, they are definitely capable of winning the second match. Ludogorets appear to struggle when playing away, particularly in Europe, where they lost all three of their visits this season.